Cynomolgus CDH3/Cadherin 3 Protein (CDH-CM103)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE
Activity: The affinity constant of 0.37 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: Asp108-Gly654

Catalog: CDH-CM103

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Product Description	Recombinant Cynomolgus CDH3/Cadherin 3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp108-Gly654.
Product Background	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.
Product Category	Recombinant Protein

Target	CDH3/Cadherin 3
Gene/Protein ID	XP_005592414.1
Species	Cynomolgus
Exact Sequence	Asp108-Gly654
Molecular Weight	The protein has a predicted MW of 61.11 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 0.37 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 20mM PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Anti-CDH3 Antibody captured on CM5 Chip via Protein A can bind Cynomolgus CDH3, His Tag with an affinity constant of 0.37 uM as determined in SPR assay (Biacore T200).
	Cynomolgus CDH3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.