Cynomolgus Oncostatin M/OSM Protein (OSM-CM102)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 1.31 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Ala27-Arg221

Catalog: OSM-CM102

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Product Description Recombinant Cynomolgus Oncostatin M/OSM Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ala27-Arg221.

Product Background

 OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

Product Category

 Recombinant Protein

Target

 Oncostatin M/OSM

Gene/Protein ID

 XP_045219762.1

Species

 Cynomolgus

Exact Sequence

 Ala27-Arg221
Molecular Weight The protein has a predicted MW of 23.31 kDa. Due to glycosylation, the protein migrates to 27-50 kDa based on Tris-Bis PAGE result.

Activity

 The affinity constant of 1.31 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus OSM, His Tag with an affinity constant of 1.31 uM as determined in SPR assay (Biacore T200).
The purity of Cynomolgus Oncostatin M is greater than 95% as determined by SEC-HPLC.
Cynomolgus Oncostatin M on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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