Name: Human DLL4 Protein (DLL-HM104)
Brand: KactusBio
SKU: DLL-HM104-100UG
Price: 214.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Human DLL4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-DLL4 Antibody, hFc Tag with the EC50 of 1.6ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Ser27-Pro524

Catalog #DLL-HM104

Size

100UG

500UG

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Human DLL4 Protein (DLL-HM104) Summary

Product Description	Recombinant Human DLL4 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ser27-Pro524.
Product Background	Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human DLL4 Protein (DLL-HM104) Specifications/Details

Protein	DLL4
Synonyms	DLL-4; MGC126344; notch ligand DLL4; Delta4; Delta-like 4
Accession	KT340-D
Species	Human
Biotinylated	no
Amino Acid Range	Ser27-Pro524
Molecular Weight	The protein has a predicted MW of 55.38 kDa. Due to glycosylation, the protein migrates to 56-70 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human DLL4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-DLL4 Antibody, hFc Tag with the EC50 of 1.6ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS, 200 mM L-Arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human DLL4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-DLL4 Antibody, hFc Tag with the EC50 of 1.6ng/ml determined by ELISA.
	Human DLL4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human DLL4 is greater than 90% as determined by SEC-HPLC.