Human IL-3 R Beta/CD131 Protein (IL3-HM2RB)

Human IL-3 R Beta, hFc Tag captured on CM5 Chip via Protein A can bind Human GM-CSF, No Tag with an affinity constant of 6.78 uM as determined in SPR assay (Biacore T200) (QC Test).

Human IL-3 R Beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human IL-3 R Beta is greater than 90% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: The affinity constant of 6.78 uM as determined in SPR assay (Biacore T200).
Amino Acid Range: Thr17-Trp443

Catalog #IL3-HM2RB

Price

$346⁵⁰

Size

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Human IL-3 R Beta/CD131 Protein (IL3-HM2RB) Summary

Product Description

Recombinant Human IL-3 R Beta/CD131 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Thr17-Trp443.

Product Background

Interleukin-3 receptor (IL-3R) is a heterodimer that comprises an IL-3 specific alpha chain (IL-3R alpha) and a common beta chain (beta C) that is shared with the receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. The beta c subunit does not bind any cytokine by itself but is involved in the formation of high-affinity functional receptors for IL-5 and GM-CSF. These receptors belong to the cytokine receptor superfamily, but they are structurally and functionally more related to each other and thus make up a distinct subfamily.

Human IL-3 R Beta/CD131 Protein (IL3-HM2RB) Specifications/Details

Protein	IL-3 R Beta/CD131
Synonyms	CDw131; CD131; CSF2RB; IL3RB; IL5RB; AIC2A; Csfgmrb
Accession	P32927-1
Species	Human
Biotinylated	no
Amino Acid Range	Thr17-Trp443
Molecular Weight	The protein has a predicted MW of 74.63 kDa. Due to glycosylation, the protein migrates to 75-90 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 6.78 uM as determined in SPR assay (Biacore T200).
Product Tag	C-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Human IL-3 R Beta, hFc Tag captured on CM5 Chip via Protein A can bind Human GM-CSF, No Tag with an affinity constant of 6.78 uM as determined in SPR assay (Biacore T200) (QC Test).
	Human IL-3 R Beta on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human IL-3 R Beta is greater than 90% as determined by SEC-HPLC.